Marker list

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Review: Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics


Myeloid
    Mast
      marker: TPSAB1, CPA3, KIT, MS4A2 ​1 .high proportion in cancer than normal tissue; ​2. down-regulate the expression of TNF; ​3. 在不同癌症中其量与预后有正反关系; ​4. 高表达VEGFA促进血管新生 ​5. 表达IL10,TGFB, 招募Treg促进免疫抑制 ​6. 高表达PD-L1 ​7. 释放CCL3、CCL5招募T和NK
      Neutrophil
        Dendritic
          1. 在先天性和适应性免疫反应之间起到桥梁作用 2. 移动到淋巴结的次级淋巴结构，并激活初始 B 或 T 细胞
          Conventional DC (cDC)
            cDC1
              marker: XCR1, CLEC9A, BATF3, IRF8 1. mainly antitumor
              cDC2
                marker: CLEC10A, FCER1A, CD1C, CD1E 1. 促进Th2、抑制Th17、与CD4+ T互作促进肿瘤 2. activates antitumor CD4+ conventional T cells (Tconvs) in the absence of Treg
                Plasmacytoid DC (pDC)
                  marker: MZB1, LILRA4, IRF7, IL3RA 1. immunosuppressive； 2. anti-tumor: release IFNα/β & TNFα
                  LAMP3+ DC (mregDC)
                    marker: LAMP3, BIRC3, CCR7, FSCN1 1. high expression of LAMP3, immune regulators [CD274 & FAS], maturation genes (CD40 & CD80) and migratory genes (CCR7 & FSCN1) 2.enriched in intratumor & invasive margin tumor tissues; 4. originate: cDC1 and cDC2,; 3. high expression of CCL17, CCL19 & CCL22; 5. suppress CD8+ T cells self-renew and function through PD-L1/PD-1 pathway; 6. interact with CD8+ T cells from cDC1 ; 7. interact with Tregs from cDC2;recuit Treg;
                    DC3
                      marker: CD88−CD1c+CD163+ 1. pro-inflammatory: trigger the expansion of tissue-resident memory CD8+ T cells and enhance MHC expression 2. intermediated functional subtype between cDC2 and monocyte, produces TNFα as monocyte & IL23, IL12p70 as cDC2
                      Monocyte
                        Classical monocyte
                          marker: FCN1, CD14, S100A8, VCAN
                          Nonclassical monocyte
                            marker: FCN1, FCGR3A, LILRB2, LST1
                            Intermediate monocyte
                              marker: FCN1, CD14, FCGR3A
                              Macrophage
                                classically activated macrophages (M1)
                                  alternatively activated macrophages (M2)
                                    Monocyte-like macrophages
                                      marker: FCN1, CD163, CD68
                                      FOLR2+ TRM
                                        marker: FOLR2, MRC1 1. enrich: tumor stroma 2. prime effector CD8+ T cells 3. beneficial to survival
                                        TREM+ recruited macrophages
                                          1. enrichment and activation of T cells and nature killer (NK) cells, which furtherly enhanced ICB therapy
                                          MDSCs-like macrophages
                                            marker: MARCO & TREM1 1. Myeloid-derived suppressor cells
                                            TAM-like macrophage
                                              marker: CD169, CX3CR1, TREM2 1. immature macrophage; 2. Enriched in TME with T cells infiltrated or excluded
                                              LYVE1+ TRM
                                                marker: LYVE1, C1QC, PLTP, SEPP1 1. locate: adjacent to blood vessels
                                                NLRP3+ TRM
                                                  marker: NLRP3, IL1B, CXCL2, EREG 1. promote the inflammatory response
                                                  Alveolar TRM
                                                    marker: PPARG, MARCO, MRC1, MSR1 1. canonical TRM
                                                    ISG15+ TAM
                                                      marker: ISG15, CXCL10, IFITM3, GBP1
                                                      C1QC+ TAM
                                                        marker: C10A, C1QB, C1QG, APOE 1. phagocytosis and antigen presentation 2. originate: FCN1+ monocytes 3. locate: adjacent zones
                                                        SPP1+ TAM
                                                          marker: SPP1, VEGFA, GPNMB, FN1 1. angiogenesis; 2. worse prognosis; 3. associate with ICB drug resistance 3. interact with tumor-specific FAP+ fibroblasts to promote tumor progression 4. SPP1+ macrophages and TREM2+ macrophages might largely be overlapped with each other
                                                          Lymphocyte
                                                            NK
                                                              1. 识别MHC-I类分子表达下调的细胞（在多种癌症类型中均表现出的一种免疫耐受现象） 2. 与肿瘤细胞上表达的应激诱导配体结合(如MICA或MICB，它们可与NK细胞上表达的NKG2D结合)。
                                                              End.